Prurigo nodularis
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References
Prurigo nodularis je dolgotrajno stanje kože, za katerega so značilne številne čvrste izbokline in vozliči, ki se običajno nahajajo na zunanjih delih rok in nog. Barva teh izboklin je lahko od mesnate do rožnate in močno srbijo. Lahko prizadenejo ljudi katere koli starosti in so pogosto povezani z drugimi kožnimi boleznimi, ki povzročajo kronično srbenje, kot je atopijski dermatitis. Možnosti zdravljenja vključujejo močna zdravila proti srbenju, zdravila, ki vplivajo na imunski sistem, in zdravila, ki delujejo na živčni sistem. Obvladovanje prurigo nodularis običajno vključuje dolgotrajno zdravljenje.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Zdravljenje običajno vključuje uporabo krem ali injekcij steroidov na prizadetem območju. V hujših ali trdovratnih primerih bo morda potrebno zdravljenje, kot je svetlobna terapija ali zdravila, ki zavirajo imunski sistem. Talidomid in lenalidomid sta možnosti za hude primere, vendar imata lahko resne stranske učinke. Novejša zdravljenja (opioid receptor antagonists, neurokinin-1 receptor antagonists) so obetavna pri zdravljenju prurigo nodularis z manj stranskimi učinki v primerjavi s talidomidom ali lenalidomidom.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo je stanje kože, za katerega so značilni dolgotrajno srbenje (ki traja več kot 6 tednov) , kožne lezije, povezane s praskami, in anamneza pogostega praskanja. Vključuje nevrovnetje in fibrozo v koži.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis je dolgotrajna težava s kožo, ki jo zaznamujejo srbeči vozliči. Ne vemo natančno, kaj ga povzroča, vendar se zdi, da imunske in živčne težave igrajo vlogo v ciklu srbenja in praskanja. Trenutno ni nobenega zdravljenja, ki bi ga odobrila ameriška FDA posebej za prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Zdravljenje ― OTC zdravila
Umivanje območja lezije z milom ne pomaga prav nič in lahko poslabša stanje. OTC steroidna mazila lahko pomagajo pri lajšanju simptomov, vendar jih je običajno treba uporabljati več tednov, da se izboljšajo. Nadaljevanje jemanja antihistaminikov prav tako pomaga ublažiti srbenje.
#OTC steroid ointment
#OTC antihistamine
○ Zdravljenje
#Intralesional triamcinolone injection